Thick airway surface liquid volume and weak mucin expression in pendrin-deficient human airway epithelia
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چکیده
منابع مشابه
Thick airway surface liquid volume and weak mucin expression in pendrin-deficient human airway epithelia
Pendrin is an anion exchanger whose mutations are known to cause hearing loss. However, recent data support the linkage between pendrin expression and airway diseases, such as asthma. To evaluate the role of pendrin in the regulation of the airway surface liquid (ASL) volume and mucin expression, we investigated the function and expression of pendrin and ion channels and anion exchangers. Human...
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Thomas Gray,* Ray Coakley,* Andrew Hirsh, David Thornton, S. Kirkham, Ja-Seok Koo, Lauranell Burch, Richard Boucher, and Paul Nettesheim Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park 27709; Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599-7248; Department o...
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ژورنال
عنوان ژورنال: Physiological Reports
سال: 2015
ISSN: 2051-817X
DOI: 10.14814/phy2.12480